![]() Thus the familial excess (SIR-1.00) was more than two fold higher for right-sided colon cancer. The SIRs for colon cancer in age matched populations were 2.58 when parents were probands and 3.81 when siblings were probands for right-sided colon cancer the SIRs were 3.66 and 7.53, respectively. ![]() The excess risk was limited to colon cancer and particularly to right-sided colon cancer. As a novel finding it was shown that risks for siblings were higher than those for offspring of affected parents. Familial standardized incidence ratios (SIRs) were determined for offspring when parents or sibling were diagnosed with colon or rectal cancer. We show one application of the Database in the study of familial risks in colorectal adenocarcinoma, with defined age-group and anatomic site specific analyses. Compared to previous versions, only 6.0% of deceased offspring with a cancer diagnosis lack any parental information. Cancer cases were retrieved from the Swedish Cancer Registry from 1958-2002, including over 1.2 million first and multiple primary cancers and in situ tumours. This update included all Swedes born in 1932 and later (offspring) with their biological parents, a total of 10.5 million individuals. ![]() ![]() In the present paper we describe some main features of version VI of this Database, assembled in 2004. The Swedish Family-Cancer Database has been used for almost 10 years in the study of familial risks at all common sites. ![]()
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